THE ANTIDIABETIC EFFECT OF MSCS IS NOT IMPAIRED BY INSULIN PROPHYLAXIS AND IS NOT IMPROVED BY A SECOND DOSE OF CELLS.

The antidiabetic effect of MSCs is not impaired by insulin prophylaxis and is not improved by a second dose of cells.

Type 1 diabetes mellitus (T1D) is due to autoimmune destruction of pancreatic beta-cells.Previously, we have shown that intravenously administered bone marrow-derived multipotent mesenchymal stromal cells (MSCs) allows pancreatic islet recovery, improves insulin secretion and reverts hyperglycemia in low doses streptozotocin (STZ)-induced diabetic

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